AIDS - What is Chemokine Receptor 4

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AIDS - What is Chemokine Receptor 4

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1. aids chemokine receptor 4

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• A duodenally absorbable CXC chemokine receptor 4 antagonist, KRH 1636, exhibits a potent and selective anti-HIV-1 activity


• A breakthrough in our understanding of HIV pathogenesis was the identification of a chemokine receptor like molecule in 1996, called LESTR, subsequently designated as CXCR-4, as a necessary co-receptor for X 4 variants of HIV entry into cells


• There are two major co-receptors chemokine (C-C motif) receptor 5 (CCR-5) and chemokine (C-X-C motif) receptor 4 (CXCR-4) and all HIV-1 strains use one or both of them

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