AIDS - What is Optimized Background Therapy (OBT)

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AIDS - What is Optimized Background Therapy (OBT)

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1. aids optimized background therapy

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• Safety and Efficacy of Maraviroc (MVC), a Novel CCR5 Antagonist, when Used in Combination with Optimized Background Therapy (OBT) for the Treatment of Antiretroviral-Experienced Subjects Infected with Dual/Mixed-Tropic HIV-1: 24-Week Results of a Phase 2b Exploratory Trial


• , optimized background therapy [OBT])


• with an optimized background therapy that must include a protease inhibitor


2. ob

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• Objective To describe HIV-1 DNA levels from baseline (W0) to week 52 (W52) among patients receiving either interleukin-2 (IL-2) optimized background therapy (OBT) or OBT as salvage treatment


• Enfuvirtide (ENF), the first HIV--fusion inhibitor, has shown potent and sustained antiviral activity when administered in combination with optimized background (OB) therapy to treatment-experienced, HIV-1- infected individuals and has a favourable safety profile


• The additional 48-week optional treatment extension of the T-20 versus Optimized Regimen Only (TORO) studies evaluated long-term safety and efficacy of enfuvirtide (ENF) through week 96 in patients receiving ENF plus optimized background (OB) and patients switching to ENF plus OB from OB alone

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