AIDS - What is Myopathy

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AIDS - What is Myopathy

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1. aids myopathy

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• Our results suggest that, in the process of AIDS myopathy development, AZT or oxidative agents directly impair the energy-producing system of mitochondria, causing dysfunction of cellular redox control, which eventually leads to loss of the mitochondrial DNA integrity


• Zidovudine (AZT), the first-line antiretroviral therapy in patients with AIDS can induce a reversible toxic mitochondrial myopathy in patients who have received high cumulative doses of the drug


• As mitochondrial dysfunction related to zidovudine is associated with impaired activity of COX [cytochrome c oxidase], we evaluated the COX histochemical reaction for the diagnosis of zidovudine myopathy

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