AIDS - What is increased risk lactic acidosis

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AIDS - What is increased risk lactic acidosis

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1. aids increased risk lactic acidosis

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• There is no evidence from prospective comparative trials or from observational cohort studies that metformin is associated with an increased risk of lactic acidosis, or with increased levels of lactate, compared to other anti-hyperglycemic treatments


• alterations involves NRTI-therapy interruption and supportive care, while natural history of hyperlactataemia is still unknown, and it is uncertain whether asymptomatic patients with increased lactate concentrations are at increased risk of developing lactic acidosis


• The routine use of D4T and DDI as a component of HAART is not currently recommended, because of the increased risk of lactic acidosis and other toxicities2,4-6,7

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