AIDS - What is Endpoint

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AIDS - What is Endpoint

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1. aids endpoint

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• As a result of the growing evidence that the suppression of HIV-1 replication by antiretroviral drugs reduces the risk of progression to AIDS and death , many current and planned clinical trials of antiretroviral regimens use some measure of durability of HIV-1 suppression as the primary efficacy endpoint


• The authors would like to thank members of the HIV Disease Research Agenda Committee of the Adult AIDS Clinical Trials Group and physicians at the University of California San Francisco for participating in a primary virological endpoint survey


• CD4 cell count is a weak surrogate endpoint, but has some value as an aid for screening treatments for drug development or preliminary regulatory approval

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